Cell Operations Amaze, Inspire

first_img An analysis of complexes with large chimeric oligonucleotides shows that the basic tails of both proteins are attached flexibly, enabling them to bind rigid duplex DNA segments extending from the core in different directions. Our results indicate that the basic tails of DEAD-box proteins contribute to RNA-chaperone activity by binding nonspecifically to large RNA substrates and flexibly tethering the core for the unwinding of neighboring duplexes. Electric cells:  You’ve heard of electric eels; how about electric bacteria?  Researchers at Harvard, publishing in Science, were curious about the electrical properties of cells: Antenna tower construction crew:  Cilia are complex organelles in the cell membrane that protrude into the intercellular medium, where they can sense the surroundings and perform other functions.  Some are motile, like the cilia in the human respiratory tract that sweep foreign matter out with coordinated strokes.  Cells build cilia using molecular ore-carts powered by kinesin-2 motors in a process called intra-flagellar transport (IFT), in which components are hoisted up into the cilium on trackways.  Scientists suspected that additional factors regulate the construction of cilia.  Now, two American molecular biologists publishing in Current Biology identified one such member of the construction crew, named KLP6, that moves independently of kinesin-2 and acts to reduce its velocity.  Note: they found this in a particular kind of cell in a roundworm. Gatekeeper dance:  Ion channels play many vital roles in our bodies.  According to Science Daily, they are “essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability.”  One such channel, named BK, performs large conductance of potassium ions in the presence of calcium ions.  Scientists had thought that all ion channels followed a unified theory of activation.  Researchers at the University of Texas at Austin have found that BK channels are not that simple.  DNA orchestra:  An article on PhysOrg about DNA translation begins, “Just like orchestra musicians waiting for their cue, RNA polymerase II molecules are poised at the start site of many developmentally controlled genes, waiting for the ‘Go!’-signal to read their part of the genomic symphony.”  Researchers at Stowers Institute for Medical Research found that Super Elongation Complex (SEC), an assembly of some 10 transcription elongation factors, conveys the downbeat to the translation machine and “helps paused RNA polymerases to come online and start transcribing the gene ahead”.  This quick-start device “reduces the number of steps required for productive transcription and allows cells to respond quickly to internal and external signals,” one of the researchers explained.  Continuing the orchestra metaphor, the article said, “Transcriptional control by RNA polymerase II (Pol II) is a tightly orchestrated, multistep process that requires the concerted action of a large number of players to successfully transcribe the full length of genes.” Quality control inspectors:  At the exit gate of the ribosome, where new proteins have just been assembled, molecular machines called chaperones stand at the ready to help them fold properly.  A Stanford team studied two of these, the Signal Recognition Particle (SNP) and Nascent Chain associated Complex (NAC), which have the remarkable ability to work on a wide variety of proteins, helping them fold properly.  Publishing in PLoS Biology, they said, The Science Daily article reported that a team at Howard Hughes Medical Institute produced the highest-resolution diagram ever of a sodium channel .  In this excerpt, you can sense the fascination as the team looked down the channel for the first time in such detail: “We hope to gain insight into why they selectively let in sodium ions and nothing else,” the researchers said, “and how they respond to changes in the cell membrane voltage, how they open and close, and how they generate electrical signals.”  The researchers have already spotted intriguing molecular movement, such as rolling motions of some functional parts of the sodium channel molecule and their connectors…. Bacterial membrane potential provides a major component of the driving force for oxidative phosphorylation, membrane transport, and flagellar motion. Yet this voltage is inaccessible to techniques of conventional electrophysiology, owing to the small size of bacteria and the presence of a cell wall. Little is known about the electrophysiology of bacteria at the level of single cells. So they checked.  They observed E. coli bacteria producing electrical spikes at a rate of about one per second.  The electrical charge is generated by ion channels in the membrane that create electrical gradients, working against the natural tendency of charges to cancel out.  “Spiking was sensitive to chemical and physical perturbations and coincided with rapid efflux of a small-molecule fluorophore,” they said, “suggesting that bacterial efflux machinery may be electrically regulated.”  In other words, they were not observing a stochastic effect, but a coordinated action of many ion channels that must organize their active transport mechanisms as a unit.  They speculated that the spiking represents a stress response by the organism.  Coordinated electrical response is known in higher organisms, like electric eels and humans, but “These simple estimates show that some of the tenets of neuronal electrophysiology may need rethinking in the context of bacteria.” Salt of the cell:  If you enjoy having a healthy heart, brain and pancreas, thank your sodium channels.  Like the BK potassium channels, sodium channels regulate a wide range of physiological activities.  According to Science Daily, “Mutations in voltage-gated sodium channels underlie inherited forms of epilepsy, migraine headaches, heart rhythm disturbances, periodic paralysis, and some pain syndromes.”  When the dentist numbs your gums, he is effectively blocking the local sodium channels from doing their job – sending pain messages to the brain.  “The ribosome uses two active mechanisms to unwind messenger RNA during translation.” (Nature)  “Crystal structures of [lambda] exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity.” (PNAS) “Mechanism of activation gating in the full-length KcsA K+ channel.” (PNAS) We further show interactions between the peptidyl-prolyl isomerase and Trp-Trp (WW) domains amplify the conduit response, and alter binding properties at the remote peptidyl-prolyl isomerase active site. These results suggest that specific input conformations can gate dynamic changes that support intraprotein communication.  Such gating may help control the propagation of chemical signals by Pin1, and other modular signaling proteins. RNA linemen:  We’ve all watched in the movies how rescue workers toss a line over a wall or pole so that they can climb up.  Something like that happens with some machines that unwind RNA.  In PNAS, a team of researchers described a helicase with the awful name “mitochondrial DEAD-box protein Mss116p” that acts as a general RNA chaperone.  (They really should give these machines better names, like the Chuck Norris Hammerlock Clamp.)  Not only does the machine clamp down on the RNA, it first latches onto it by means of a couple of tails that fasten onto the RNA, tethering the machine to its target: Transport vesicles are created when coat proteins assemble on a flat membrane, select cargo, and deform the membrane into a bud. The budded vesicle is then carried to its target organelle, where it docks by means of ‘tethers’ before undergoing membrane fusion. The vesicle coat was once thought to fall off as soon as budding was complete, but we now know the coat is important for binding the tethering factors that help the vesicle identify the correct organelle. Coat proteins and tethers must be removed before fusion can take place, but what triggers their disassembly has always been a mystery. A paper recently published in Nature now shows that, when one kind of transport vesicle docks with its target membrane, it encounters a kinase that breaks the bond between the coat proteins and the tethers, kick-starting the disassembly process. The problem she was considering was how the steps are coordinated: “how can a vesicle hang onto its coat long enough to reach its target, but shed it once it arrives?”  Part of the answer appears to be in good management.  Though not yet fully understood, “These results paint a picture of Sec23 as a master regulator of budding and fusion, participating in successive interactions that are regulated by phosphorylation.”  She added, though, that “While this is an attractive model, it may not be the whole story.”  Other protein machines interact in vital ways with Sec23.  Her diagram illustrates several pieces locking together like Lego blocks, arriving and releasing at precise times in a process reminiscent of a space shuttle docking with the space station.  This complexity undermines a claim on PhysOrg that “Endocytosis is simpler than expected.”  There, researchers in the Netherlands found a simpler model for the way the coat molecules (clathrin) rearrange from flat to spherical during the process of vesicle formation.  That’s only a minor aspect of a much larger multi-stage process involving many protein parts, and as this animation shows, the geodesic-style clathrin molecules are pretty clever little building blocks. Rubber baby copper pumper:  In “Structural biology: A platform for copper pumps,” Nigel Robinson, writing in Nature, said, “Copper is vital to most cells, but too much is lethal. The structure of a protein that pumps copper ions out of the cytosol provides insight into both the pumping mechanism and how certain mutations in the protein cause disease.”  His diagram shows a molecular machine called LpCopA, comprised of at least 5 protein domains, that safely pumps copper ions out of the cell.  First, the ions have to be delivered to the pump with special chaperone molecules that know how to handle it safely.  Inside the pump are three binding sites that deliver the ion to an L-shaped platform that gently holds the ion while undergoing conformational changes like a lever arm, ejecting the ion safely to the outside.  Then the platform resets for the next round.  Serious brain diseases can occur when these pumps are damaged by mutations. Our results provide new insights into SRP selectivity and reveal that NAC is a general cotranslational chaperone. We found surprising differential substrate specificity for the three subunits of NAC, which appear to recognize distinct features within nascent chains. Our results also revealed a partial overlap between the sets of nascent polypeptides that interact with NAC and SRP, respectively, and showed that NAC modulates SRP specificity and fidelity in vivo. These findings give us new insight into the dynamic interplay of chaperones acting on nascent chains. Stereo amplifier:  Researchers at Notre Dame and Virginia Tech found that an important signaling enzyme named Pin1 is stereoselective.  “Pin1 is a modular enzyme that accelerates the cis-trans isomerization of phosphorylated-Ser/Thr-Pro (pS/T-P) motifs found in numerous signaling proteins regulating cell growth and neuronal survival,” they wrote in PNAS, showing that conduit response differs if the enzyme binds on one channel instead of the other.  Here’s the scoop for bio-geeks: A student’s view of a cell under a light microscope is misleading.  It reveals only a tiny fraction of what is really going on.  Within that package of life, invisible to the student’s gaze, complex machines work together in cellular factories.  Signals pass back and forth in complex networks.  Libraries of code are transcribed and translated into machine parts.  Security guards open and close gates, and emergency response teams repair damage.  Even a simple bacterial cell has the equivalent of a city council, library, fire department, police department, industrial center, transportation infrastructure, disposal and recycling center, civil defense system and much more.  Here are just a few snippets from recent scientific papers that zoom in past the microscope lens to reveal wonders unimagined just a few decades ago. Halfway down in the activation channel, a certain amino acid residue M314 in one of the transmembrane proteins does a little dance, “rotating its side chain from a position in the closed state not exposed to the hydrophilic pore to one that is so exposed in the open state.”  This conformational change is part of a larger validation process that ensures only the right ions make it through the selectivity filter.  M314 “might not actually form the part of the activation gate that blocks ion passage, but that motions in the deep pore may be required for blocking ion passage elsewhere in the channel,”  the article explained.  So much for unified theories; “Importantly, they say, the study demonstrates that BK channel activation is not an open-and-shut case as previously suspected.” Readers may wish to investigate these additional papers published this month with intriguing titles: Dirigible doughboys:  Sometimes cells build dirigible-like “transport vesicles” out of parts of the cell membrane, to float large cargo molecules to other organelles in the cell.  This complex process involves many players, including proteins that coat the vesicle, and dockers that hold the dirigible when it comes in for landing; in the case of the cell, though, the dirigible’s coat fuses with the target organelle, so that the contents can enter safely through a membrane tunnel.  Elizabeth Conibear [U of British Columbia] introduced some of the complexity of this process, called endocytosis, in Current Biology, saying, “When a coated transport vesicle docks with its target membrane, the coat proteins and docking machinery must be released before the membranes can fuse. A recent paper shows how this disassembly is triggered at precisely the right time.”  The first paragraph of her review article described just a fraction of what goes on in these operations: Time does not permit referencing all these papers; click on the links to go to the abstracts.  These represent part of the backlog of papers on cellular wonders.  Each of them deserve a complete discussion.  Many of them talk about how parts are “highly conserved [i.e., unevolved] from bacteria to humans,” and none of them attempt even a minimally-plausible account of how they might have emerged by chance.  In these exciting days of opening the cellular black box, we should be standing in awe of the design (and the Designer), not ascribing the machinery inside to mindless, purposeless nothingness.  The record speaks for itself.  Researchers need Darwin like alcoholics need wine (Dar-wine).  It turns them into WINOs, Wesearchers In Name Only (to be pronounced with a drunken drawl).(Visited 25 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

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NBA announces 2019 All-Star game will be held in Charlotte

first_imgDon’t miss out on the latest news and information. The league had selected Charlotte to host the 2017 All-Star game, but later moved the game to New Orleans because of the state law restricting the rights of LGBT people. However, a compromise was struck in March to partially erase the impact of the House Bill 2 law limiting anti-discrimination protections for lesbians, gays, bisexual and transgender people.“While we understand the concerns of those who say the repeal of HB2 did not go far enough, we believe the recent legislation eliminates the most egregious aspects of the prior law,” NBA Commissioner Adam Silver said in a release. “Additionally, it allows us to work with the leadership of the Hornets organization to apply a set of equality principles to ensure that every All-Star event will proceed with open access and anti-discrimination policies.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSMalditas save PH from shutoutSPORTSPrivate companies step in to help SEA Games hosting“All venues, hotels and businesses we work with during All-Star will adhere to these policies as well.”Despite Silver’s intentions, the Equality NC and the Human Rights Campaign has concerns that no protections for non-discrimination policies for the LGBTQ community have been put in place by the Charlotte or the state. Cayetano dares Lacson, Drilon to take lie-detector test: Wala akong kinita sa SEA Games Sports Related Videospowered by AdSparcRead Next More than 5,000 measles deaths in DR Congo this year — WHO Adam Silver, commissioner of the National Basketball Association announces that the 2018 NBA All-Star game will be held in Los Angeles at Staples Center during a press conference at Staples Center on March 22, 2016 in Los Angeles, California. Sean M. Haffey/Getty Images/AFPCHARLOTTE, NORTH CAROLINA—The NBA All-Star game is headed back to Charlotte in 2019, a couple of years later than anticipated.The NBA announced that the All-Star weekend will be held Feb. 15-17 in Charlotte and the game will be played at the Spectrum Center, home of the Charlotte Hornets.ADVERTISEMENT Panelo suggests discounted SEA Games tickets for students PLAY LIST 01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes LOOK: Vhong Navarro’s romantic posts spark speculations he’s marrying longtime GF South Korea to suspend 25% of coal plants to fight pollution ‘Coming Home For Christmas’ is the holiday movie you’ve been waiting for, here’s why LATEST STORIES SEA Games: PH beats Indonesia, enters gold medal round in polo MOST READ Going, going, gone at French Open Pagasa: Kammuri now a typhoon, may enter PAR by weekend “North Carolina’s discriminatory law prohibits the city of Charlotte from implementing non-discrimination protections for LGBTQ residents and visitors attending the All-Star Game. Nothing has changed that fact,” said HRC senior vice president for policy and political affairs JoDee Winterhof.The NBA is the latest sports entity to return events to North Carolina; the NCAA and the Atlantic Coast Conference also are bringing events back to the state after changes were made to the law.The now-repealed House Bill 2 required transgender people to use restrooms corresponding to the sex on their birth certificates in many public buildings. That’s been dropped, but LGBT advocates have denounced the replacement law because state officials took no action barring sexual identity and gender discrimination in workplaces, restaurants and hotels and instead prohibited local governments from acting on their own.Hornets owner and longtime NBA great Michael Jordan said in a release he is “thrilled” the game is coming back to Charlotte.“We want to thank Commissioner Silver for his leadership throughout this process and for the decision to bring NBA All-Star back to Buzz City,” Jordan said in the release. “All-Star Weekend is an international event that will provide a tremendous economic impact to our community while showcasing our city, our franchise and our passionate Hornets fan base to people around the world.”ADVERTISEMENT Jordan asked Silver to keep the city in mind for 2019 after the league moved the 2017 game – hopeful the HB2 law would eventually be repealed.Silver honored that request.Hornets COO and president Fred Whitfield represented the Hornets and Spectrum Center in doing whatever he could to help facilitate a resolution, spending time meeting with legislatures and other business leaders in North Carolina.“From the very beginning I was in engaged to see if we could not only save the 2019 All-Star game, but the NCAA (basketball) regionals and the ACC Tournament, as well as concerts and events in the building,” Whitfield said. “We are operators of the building and we felt like we had to get engaged to assist to get some resolution.”Even as talks to repeal HB2 stalled at times, the Hornets continued to move forward with the league’s request to upgrade the arena.The $41 million renovation – $33.5 million of which came from the City of Charlotte – is almost complete, and has included a new scoreboard, new floor and renovations to suites and hospitality areas, among other upgrades.Charlotte previously hosted the All-Star game in 1991 at the Charlotte Coliseum, which has since been demolished.Pete Guelli, the Hornets executive vice president and chief sales and marketing officer, estimates a $100 economic impact for the city, but said the reputational effect will be even bigger.“This city has changed significantly since the last time it hosted a game 28 years ago,” Guelli said, “and the opportunity to showcase that on an international stage is incalculable.” Lakers win 9th straight, hold off Pelicans View commentslast_img read more

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Porteria tows Ceres to group lead

first_imgOil plant explodes in Pampanga town SEA Games hosting troubles anger Duterte ‘We are too hospitable,’ says Sotto amid SEA Games woes PDEA chief backs Robredo in revealing ‘discoveries’ on drug war MOST READ Don’t miss out on the latest news and information. US judge bars Trump’s health insurance rule for immigrants The win gave Ceres the early lead in Group G after Becamex Binh Duong of Vietnam and Persija Jakarta of Indonesia battled to a goalless draw at Bung Karno Stadium in Jakarta.“Credit to everyone in the team for putting in a shift tonight,” Porteria said.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine ‍football chiefSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesPorteria produced a composed finish to a flowing move in the 17th minute for the opening goal. View comments Urgent reply from Philippine ‍football chief Go: Search for ‘perfect, honest man’ to lead PNP still on PLAY LIST 01:31Go: Search for ‘perfect, honest man’ to lead PNP still on01:07Nothing wrong with raids on offices of progressive groups—Palace00:50Trending Articles02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Private companies step in to help SEA Games hosting Well-rested Dyip end three-game skid, shut down Bolts BACOLOD CITY—Midfielder OJ Porteria rediscovered his scoring touch on Tuesday night, but Ceres Negros’ defensive frailties once again came to the fore even in a 3-2 victory over Myanmar side Shan United at the start of the AFC Cup at Panaad Stadium.Porteria bagged a brace with his second goal three minutes from time ensuring the Busmen survived a second-half fightback from the visitors in front of close to 6,000 fans in Bacolod City.ADVERTISEMENT Grace Poe files bill to protect govt teachers from malicious accusations Sports Related Videospowered by AdSparcRead Next LATEST STORIESlast_img read more

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Scotland vs Netherlands: Team news & TV guide

first_imgScotland v Netherlands Scotland vs Netherlands: TV channel, stream, kick-off time, odds & match preview Ryan Kelly Last updated 2 years ago 18:50 11/9/17 FacebookTwitterRedditcopy Comments(0) Andy Robertson Scotland Getty Images Scotland v Netherlands Scotland Netherlands Friendlies Interim boss Malky Mackay leads an experimental squad into the friendly clash against a demoralised Oranje in Aberdeen Both Scotland and the Netherlands will be watching the 2018 World Cup from afar after they failed to qualify, so the final international break of 2017 will allow them to begin the process of recovery.Since the conclusion of their qualification campaigns, there have been a number of changes to both teams, with the Scots parting company with manager Gordon Strachan and the Dutch losing their star player Arjen Robben to retirement.Having endured the disappointment of missing the World Cup, both sides will be eager to give their fans something to cheer about at Pittodrie as they bring the curtain down on a year to forget. Article continues below Editors’ Picks Lyon treble & England heartbreak: The full story behind Lucy Bronze’s dramatic 2019 Liverpool v Man City is now the league’s biggest rivalry and the bitterness is growing Megan Rapinoe: Born & brilliant in the U.S.A. A Liverpool legend in the making: Behind Virgil van Dijk’s remarkable rise to world’s best player Game Scotland vs Netherlands Date Thursday, November 9 Time 19:45 GMT / 14:45 ET TV CHANNEL & LIVE STREAM Daley Blind NetherlandsIn the United Kingdom (UK), the match will be available to watch live on television on Sky Sports Football and by live stream via Sky Go. UK TV channel Online stream Sky Sports Football Sky Go In the United States (US), the match will be available to watch live on television on ESPN 3 and by live stream using WatchESPN. US TV channel Online stream ESPN 3 WatchESPN SQUADS & TEAM NEWS Position Scotland players Goalkeepers Archer, Gordon, Marshall Defenders Berra, Cooper, Hanlon, Mulgrew, Paterson, Robertson, Tierney Midfielders Armstrong, Brown, Forrest, Fraser, Jack, McGinn, McGregor, McLean, Phillips, Shinnie  Forwards Christie, Cummings Interim head coach Malky Mackay has named an experimental Scotland squad that is missing a number of key players. Captain Darren Fletcher and Celtic’s Leigh Griffiths have withdrawn from the squad.There are eight uncapped players in the panel, including Aberdeen captain Graeme Shinnie and Celtic midfielder Callum McGregor, but there is no place for the likes of Jordan Rhodes or Robert Snodgrass.Potential Scotland starting XI: Gordon; Jack, Berra, Tierney, Robertson; Forrest, Armstrong, McLean, Christie; McGregor; Phillips. Position Netherlands players Goalkeepers Cillessen, Vorm, Zoet Defenders Ake, Van Dijk, Hoedt, De Ligt, Rekik, Tete, Veltman Midfielders Van de Beek, Blind, Van Ginkel, Propper, Sneijder, Strootman, Vilhena, Wijnaldum Forwards Babel, Berghuis, Depay, Dost, Janssen, Locadia, Promes The Netherlands have one glaring absentee in the form of Arjen Robben, who announced his retirement from international football following their failure to qualify for the World Cup.However, Wesley Sneijder returns to the panel, as does Feyenoord’s Steven Berghuis, while Donny van de Beek and Jurgen Locadia could earn their first caps.Potential Netherlands starting XI: Cillessen; Ake, Van Dijk, De Ligt; Blind, Wijnaldum, Propper, Sneijder; Depay, Janssen, Promes.BETTING & MATCH ODDS Kieran Tierney, Scotland trainingThe Netherlands are 21/20 favourites to win the game according to dabblebet, with Scotland priced at 5/2 to beat the Dutch. A draw between the sides in Aberdeen is considered a 9/4 bet.Click here to see all the dabblebet’s markets and odds for the game, such as first goalscorer, correct score and more.GAME PREVIEW Memphis Depay NetherlandsMissing out on a place at the World Cup will have hurt both nations, but for three-time finalists the Netherlands, it is perhaps more keenly felt.Traditionally one of the chief forces of European football, the Dutch team’s inability to reach the biggest stage in football follows their failure to reach Euro 2016 and, as such, has prompted serious questions as to what the future holds.While they are now without stars such as Arjen Robben, the Netherlands still boast a clutch of high quality – and relatively young – players, such as Memphis Depay, Daley Blind and Virgil van Dijk. However, the new generation have much to prove in the coming years.The proverbial changing of the guard begins with their clash against the Scots – themselves in need of a radical overhaul – and they will be determined to end the year on a high note against Romania five days later.last_img read more

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Sansui launches new range of techpowered products

first_imgJapanese Consumer Electronics giant and one of the leading consumer electronic companies in India, Sansui, launched a new range of technologically powered consumer durable and electronic products in the India market, recently. The diverse product portfolio includes smart Televisions, Washing Machines, Audio Devices, Air Conditioners, Refrigerators, Small Kitchen Appliances etc. and will be available in the market from Septembwer’19 across offline and online platforms. Sansui has collaborated with major players including leading global internet entertainment service providers Netflix and Dolby as well as technology partners Google and MediaTek, to ensure a smart and enhanced TV viewing experience in its latest range. Also Read – The Puja carnivalIn-line with the Government’s thrust on ‘Make in India’, Sansui also announced setting up of a state-of-the-art manufacturing unit for TVs, washing machines, refrigerators and air-conditioners spread over 30 acres in Gurugram by June 2020. The new facility will serve as a key manufacturing hub for Sansui in South East Asia besides generating around 3000 new employment opportunities in the country. Sansui, recently, announced a strategic partnership with Delhi-based business conglomerate Jaina Group to consolidate its presence in the India and South East Asian markets. The group plans to invest 1000 crores in Indian operations in the next three years and is eyeing a turnover of INR 3500 crore for the Sansui brand in India by FY 2022. Building on its expertise of handling global brands in India, Jaina Group will make Sansui products available through 6000+ retail partners and a robust after sales service network of over 400 service centres, 2250 + certified field engineers and pin code coverage of 96%. The products will also be available through online partners like Flipkart. With a focus on honest and fair pricing and keeping in mind the forthcoming festive season, Sansui’s latest range is priced attractively across product categories. Also Read – Wave City brings special offers this NavratraSpeaking on the occasion, Pradeep Jain, Managing Director, Jaina Group said, “Jaina Group has been representing global digital brands in India for 25 years through localised solutions. With the Indian appliance and consumer electronics market expected to increase at a nine per cent CAGR to reach Rs 3.15 trillion (US$ 48.37 billion) in 2022, we are confident of growing Sansui’s market share in India and are eyeing double digit market share by FY22. Encouraged by the Finance Minister’s recent announcements aimed at boosting investments and supporting the Make in India initiative, we look forward to making India a global manufacturing hub for Sansui. Our extensive distribution network is our key strength and we will work towards strengthening the channel base further to ensure easy availability and after sales servicing of products across all corners of the country.” Visiting Sansui Executive Lim Jew Tim, Head- Global Licensing said, “India is a key growth market for Sansui and our partnership with the reputed Jaina group reiterates our intention to market our products across the country. We have a long-term commitment towards providing premium products at value for money prices to the end customer in the country and to ensure this we will soon be setting up our manufacturing unit in India in lines with the incentives provided by the Government under the Make In India initiative.” According to Dr Abhishek Garg, Executive Director, Jaina Group and Brand Head, Sansui India, “The video entertainment devices market will especially see a rapid growth and we hope to establish our niche in this segment through our focus on a series of technologically-driven, India specific products.” Through its renowned Japanese technology, Sansui brings the perfect combination of features and aesthetics with its new range of consumer durables and electronics. The range is targeted at millennials, who are brand conscious and have a preference for innovative lifestyle products.last_img read more

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Washington India needs the S400 Triumf missile

first_imgWashington: India needs the S-400 ‘Triumf’ missile defence system and has apprised the Trump administration of its decision to acquire them from Russia, External Affairs Minister S Jaishankar has said, exuding confidence that the US would appreciate its rational. India announced its intention to acquire Russian-made S-400 surface-to-air missile systems in 2015. The delivery contract worth USD 5.43 billion was signed during the visit by Russian President Vladimir Putin to India last year. Also Read – India gets first tranche of Swiss account details under automatic exchange framework Senior Trump administration officials have cautioned India that the S-400 deal could attract sanctions under the Countering America’s Adversaries Through Sanctions Act (CAATSA) law that restricts defence purchases from Russia, Iran and North Korea. Responding to a question on the S-400 missile system purchase, Jaishankar, who is here on an official visit, said, “India has made a decision on the S-400 and we have discussed that with the US government. Also Read – Afghan Taliban frees 3 Indian hostages in exchange for 11 top militant leaders: Reports “I am reasonably convinced of the powers of my persuasion ,” Jaishankar said, responding to a question from a Russian journalist on the possibility of US sanctions on India under CAATSA if New Delhi goes ahead with its decision to purchase the S-400 missile defence system from Russia. “It would be my hope that people understand why this particular transaction is important for us, so I think of your question to me is hypothetical,” he said, during his appearance at the Centre for Strategic and International Studies (CSIS), a Washington DC-based top American think tank. The S-400 ‘Triumf’ is the most advanced long-range air defense missile system that went into service in Russia in 2007. It is designed to destroy aircraft, cruise and ballistic missiles, including medium-range missiles, and can also be used against ground installations. The S-400 can engage targets at a distance of 400 km and at an altitude of up to 30 kilometres. During Prime Minister Narendra Modi’s visit to the Far East Russian port city of Vladivostok last month, India and Russia decided to start manufacturing spare parts and components for the Russian military equipment in India under transfer of technology and set up joint ventures, as the two strategic partners tried to transform their existing buyer-seller relationship into one of collaboration. Prime Minister Modi and Russian President Putin also pledged to elevate India-Russia partnership to new heights of cooperation. Close cooperation between Russia and India in military and military-technical areas is a key pillar of bilateral and especially privileged strategic partnership, the two leaders said. According to a joint statement, the two countries expressed their commitment to upgrading their defence cooperation, including by fostering joint development and production of military equipment, components and spare parts, improve the after-sales service system. Both countries agreed to take forward ongoing engagement to encourage joint manufacturing in India of spare parts, components, aggregates and other products for maintenance of Russian-origin arms and defence equipment under the Make-in-India programme through transfer of technology and setting up of joint ventures.last_img read more

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New Delhi Mahatma Gandhi had visited RSS shakha d

first_imgNew Delhi: Mahatma Gandhi had visited RSS shakha during the time of Partition, interacted with swayamsevaks and expressed joy over their discipline and the absence of divisive feelings over caste and creed among them, Rashtriya Swayamsevak Sangh (RSS) chief Mohan Bhagwat said.Sangh swayamsevaks recall Gandhi and his values as part of their morning prayer in Shakhas, he said while referring to ‘Ekatmata Stotra’ which is recited in the daily gatherings of its workers. Also Read – Personal life needs to be respected: Cong on reports of Rahul’s visit abroad”Gandhiji… visited a shakha near his place of residence in Delhi during the tragic days of Partition. He spoke to the swayamsevaks in the shakha. Its report was published in the Harijan, dated September 27, 1947. Gandhiji expressed his joy over the discipline of the Sangh swayamsevaks and complete absence of divisive feelings of caste and creed in them,” Bhagwat said in an article posted on the RSS website as the country celebrated the 150th birth anniversary of Mahatma Gandhi on Wednesday . Also Read – Firms staying closed 10 days a month due to recession, govt doing nothing: Priyanka GandhiGandhi had also visited a Sangh camp near Wardha in 1936 and next day RSS founder Dr Hedgewar met him at his Ashram. The contents of the long question-answer session and discussion are now in public domain, he said. Emphasising on Gandhi’s Swadeshi vision for the country, the RSS chief said the Mahatma gave a thought process that was based on giving India its own identity in all spheres of life but people with “slavish mindset” accepted western set of values as a model. He said Gandhi advocated Swadeshi philosophy as the West, on back of its political power, promoted its systems and lifestyle by distorting education and making others financially dependent. “However, without understanding this, the people with a slavish mindset accepted the western set of values as a model, denouncing our forefathers, pride and culture as inferior and disgraceful and engaged themselves in imitating and flattering the West. Its massive influence is visible in the country’s direction and condition even today,” he said. Gandhi pitched for “reorganisation of Bharat” based on self reliance, he said adding that the Father of the Nation firmly stood for social equality and harmony.last_img read more

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Houston Thousands of people from all walks of lif

first_imgHouston: Thousands of people from all walks of life turned out for the day-long ceremonies here on Wednesday to honour slain Indian-American police officer Sandeep Singh Dhaliwal, who was shot dead on duty during a traffic stop. Dhaliwal, 42, was the first Sikh sheriff’s deputy in Harris County with a population of over 10,000 Sikhs. He made national headlines when he was allowed to grow a beard and wear a turban on the job. He was gunned down while conducting a routine mid-day traffic stop in northwest of Houston on Friday. Also Read – Saudi Crown Prince Salman ‘snubbed’ Pak PM Imran, recalled his private jet from US: Report The fallen deputy’s funeral included processions, a traditional Sikh funeral and a law enforcement funeral with a 21-gun salute from fellow officers and a helicopter flyover. As ‘Amazing Grace’ was played on the bagpipes, members of Harris County Sheriff’s Office (HCSO) folded the American flag that covered his casket and Sheriff Ed Gonzalez presented it to Dhaliwal’s widow who clutched it to her heart. After final ceremonies from the law enforcement memorial service, the Dhaliwal family and members of HCSO headed to the Winford Funeral Home for a closed cremation. Also Read – Iraq military admits ‘excessive force’ used in deadly protests The procession route was lined with blue and white signs reading “Always in Our Hearts,” and “In Loving Memory of Deputy Dhaliwal.” People had posted custom yard signs, billboards and flowers all along the route and in the neighbourhood. At the service, Simratpal Singh, a US Army Captain, flanked by other members of the Sikh community in military service, described Dhaliwal as “humble, fearless, not dissuaded by negativity.” “Our lion may be gone physically but his legacy of selfless service and of breaking down barriers will continue to live,” he said. Senator Ted Cruz, R-Texas, speaking before thousands during the Sikh part of the ceremony, addressed Dhaliwal’s wife and three children in saying the community “supports you and lifts you up.” “We are grateful for your father’s service, and his sacrifice and his legacy,” Cruz said. Dhaliwal, the father of three, joined the force 10 years back and was the state’s first law enforcement officer to receive permission to wear a religious turban and beard while on duty. Commissioner Adrian Garcia who hired Dhaliwal 10 years ago said the stadium full of people and the deputy’s celebration of life was “fit for a king.” As he addressed Dhaliwal’s father, he said, “Baba, you raised a good man. You raised him with a heart of gold. It is unfair that a father should outlive his son.” Lt. Gov. Dan Patrick said he doesn’t normally speak at public funerals but he was honoured to be invited to speak at Dhaliwal’s funeral. “Since 2015, we’ve lost 50… 50 men and women of law enforcement in the line of duty and Deputy Dhaliwal was the 50th,” he said. “He (Sandeep) did more in his life than some people do in a hundred years, he added. Houston Mayor Sylvester Turner said it was “moments like these when we fall on our faith.” “He (Dhaliwal) was the ambassador of all that is good. And the way he died does not erase that,” Turner said. “In a city that happens to be the most diverse in the country, is a city, because of this one person, on this day and hopefully days to come, will be the most unified it has ever been,” added Turner. Gonzalez said Dhaliwal was a trailblazer and wore his Sikh faith on the outside for all to see. “Sandeep was an inspiration to us all and was considered to be one of our finest deputies, with a bright future to match his beautiful bright personality. I will miss the gentle smile and embrace I received each time I saw him,” he said. New Jersey Attorney General Gurbir Grewal, the nation’s first Sikh state’s attorney general, said Dhaliwal “inspired an entire generation of Sikhs” to join public service. The services on Wednesday followed a candlelight vigil by the sheriff’s office for Dhaliwal on Monday and a 48-hour-long prayer-vigil. Dhaliwal was killed in the town of Cypress after pulling over a vehicle for running a stop sign. Investigators said video from a dashboard camera shows the suspect, 47-year-old Robert Solis, getting out of his car, approaching Dhaliwal from behind and shooting him twice in the head. Police said Solis had a warrant for his arrest on parole violations and likely feared that his arrest would mean a return to prison. Solis, who has been charged with capital murder, was arrested at a nearby grocery parking lot.last_img read more

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New Delhi A day after protesting outside Sonia Ga

first_imgNew Delhi: A day after protesting outside Sonia Gandhi’s residence here over alleged irregularities in ticket distribution, former Haryana Congress chief Ashok Tanwar on Thursday resigned from all election committees of the party but said he would continue to work as an ordinary party worker. In his letter to Congress president Gandhi, Tanwar said he was stepping down from various committees formed by her for the Haryana assembly elections but would continue to work to strengthen the party as its “ordinary soldier”. Also Read – Personal life needs to be respected: Cong on reports of Rahul’s visit abroadHe alleged the Congress in Haryana had turned into “Hooda Congress” as those who worked against the party’s interests have been given prominence over those who slogged to strengthen the opposition party in the state. “I am writing this letter with immense pain to inform you that after due consideration and exhausting all available avenues to get my voice heard. I have not been left with any other option but to resign …,” Tanwar said in his letter.last_img read more

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Ranchi Two policemen were killed when Maoists ope

first_imgRanchi: Two policemen were killed when Maoists opened fire on security forces in Ranchi district in Jharkhand on Friday, a senior police officer said. Following a tip that members of the banned CPI (Maoist) group had gathered near Dassam falls between Bundu and Namkum, security forces rushed to the area around 4 am, Additional Director General of Police Murari Lal Meena told PTI. “The Maoists opened fire on the security forces and two of our district jawans suffered bullet injuries. While one jawan was declared brought dead at the hospital, another succumbed during treatment,” the ADGP said. The security forces retaliated but there was no report of any casualty from the other side, Meena said adding search operations are under way.last_img read more

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